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KMID : 0043320120350050779
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Archives of Pharmacal Research
2012 Volume.35 No. 5 p.779 ~ p.784
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Bioactive cadinane-type compounds from the soft coral Sinularia scabra
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Su Jui Hsin
Huang Chiung Yao
Li Po Ju
Lu Yi
Wen Zhi Hong
Kao Yao Haur
Sheu Jyh Horng
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Abstract
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Two new cadinane-type sesquiterpenoids, scabralins A (1) and B (2) were obtained from the soft coral Sinularia scabra. Metabolite 1 was shown to exhibit moderate to weak cytotoxicity against MCF-7, WiDr, Daoy, and HEp 2 cancer cell lines. Also, incubation with 10 μM compound 1 significantly inhibited the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
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KEYWORD
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Sesquiterpenoid, Soft coral, Sinularia scabra
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